PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators.

@article{Gonzalez2008PPARalphaMO,
  title={PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators.},
  author={Frank J. Gonzalez and Yatrik M. Shah},
  journal={Toxicology},
  year={2008},
  volume={246 1},
  pages={2-8}
}
Peroxisome proliferator chemicals are classic non-genotoxic carcinogens. These agents cause liver cancers when chronically administered to rats and mice. Peroxisome proliferators include the widely prescribed lipid and cholesterol lowering fibrate drugs. In contrast to the results in rodents, there is no evidence that fibrates are associated with elevated risk of liver cancer or any other neoplasms in humans thus indicating a species difference in the hepatocarcinogenic response. The biological… CONTINUE READING