PPARalpha, but not PPARgamma, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia.

@article{Hennuyer2005PPARalphaBN,
  title={PPARalpha, but not PPARgamma, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia.},
  author={Nathalie Hennuyer and Anne Tailleux and G{\'e}rard Torpier and Hafid Mezdour and J. -C. Fruchart and Bart Staels and Catherine Fi{\'e}vet},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 9},
  pages={1897-902}
}
OBJECTIVE Peroxisome proliferator-activated receptor (PPAR) alpha and gamma are nuclear receptors that may modulate atherogenesis, not only by correcting metabolic disorders predisposing to atherosclerosis but also by directly acting at the level of the vascular wall. The accumulation of lipid-laden macrophages in the arterial wall is an early pivotal event participating in the initiation and promotion of atherosclerotic lesion formation. Because PPARalpha and gamma modulate macrophage gene… CONTINUE READING