PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases: the Boston Puerto Rican Health Study.

@article{Lai2008PPARGC1AVA,
  title={PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases: the Boston Puerto Rican Health Study.},
  author={Chao-Qiang Lai and Katherine L Tucker and Laurence D. Parnell and Xian Adiconis and Bibiana Garc{\'i}a-Bailo and John Griffith and Mohsen Meydani and Jos{\'e} M. Ordov{\'a}s},
  journal={Diabetes},
  year={2008},
  volume={57 4},
  pages={809-16}
}
OBJECTIVE Individuals with type 2 diabetes exhibit higher DNA damage and increased risk of cardiovascular disease (CVD). However, mechanisms underlying the association between DNA damage and development of type 2 diabetes and CVD are not understood. We sought to link peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PPARGC1A), a master transcriptional regulator of mitochondrial oxidative phosphorylation and cellular energy metabolism, with DNA damage, type 2 diabetes, and… CONTINUE READING

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