PPARD rs2016520 polymorphism and circulating lipid levels connect with brain diseases in Han Chinese and suggest sex-dependent effects.

@article{Huang2015PPARDRP,
  title={PPARD rs2016520 polymorphism and circulating lipid levels connect with brain diseases in Han Chinese and suggest sex-dependent effects.},
  author={Yi Huang and Sheng Fang Nie and Shengjun Zhou and Keqin Li and Jie Sun and Jikuang Zhao and Bing Fei and Zhepei Wang and Huadan Ye and Qingxiao Hong and Xiang Gao and Shiwei Duan},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2015},
  volume={70},
  pages={
          7-11
        }
}
The PPARD polymorphisms were shown to be associated with circulating lipoprotein metabolism in various diseases. We aimed to check the contribution of PPARD rs2016520 and lipid concentration to the risk of intracerebral hemorrhages (ICH) and brain tumors (BT) in Han Chinese. A total of 864 participants were included in the case-control study. The melting temperature shift (Tm-shift) method was used for rs2016520 genotyping. Under the recessive model, PPARD rs2016520 was shown to be associated… CONTINUE READING
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