PPAR-mediated activity of phthalates: A link to the obesity epidemic?

@article{Desvergne2009PPARmediatedAO,
  title={PPAR-mediated activity of phthalates: A link to the obesity epidemic?},
  author={B. Desvergne and J. Feige and C. Casals-Casas},
  journal={Molecular and Cellular Endocrinology},
  year={2009},
  volume={304},
  pages={43-48}
}
  • B. Desvergne, J. Feige, C. Casals-Casas
  • Published 2009
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • The endocrine disruption hypothesis asserts that exposure to small amounts of some chemicals in the environment may interfere with the endocrine system and lead to harmful effects in wildlife and humans. Many of these chemicals may interact with members of the nuclear receptor superfamily. Peroxisome proliferator-activated receptors (PPARs) are such candidate members, which interact with many different endogenous and exogenous lipophilic compounds. More particularly, the roles of PPARs in lipid… CONTINUE READING
    224 Citations
    Tributyltin is a potent inhibitor of piscine peroxisome proliferator-activated receptor α and β.
    • 23
    • PDF
    Minireview: PPARγ as the target of obesogens
    • 121
    • PDF
    Reprint of “In silico methods in the discovery of endocrine disrupting chemicals”
    • 5
    In silico methods in the discovery of endocrine disrupting chemicals
    • 53
    Pulmonary phthalate exposure and asthma - is PPAR a plausible mechanistic link?
    • 17
    • PDF
    Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor α, β, γ subtypes: an in silico approach
    • 48
    Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate
    • 12
    Associations of Phthalate Metabolites and Obesity-Related Metabolic Factors
    • PDF

    References

    SHOWING 1-10 OF 56 REFERENCES
    Interference of pollutants with PPARs: endocrine disruption meets metabolism
    • 116
    • PDF
    The Endocrine Disruptor Monoethyl-hexyl-phthalate Is a Selective Peroxisome Proliferator-activated Receptor γ Modulator That Promotes Adipogenesis*
    • 258
    • PDF
    Role of PPARalpha in mediating the effects of phthalates and metabolites in the liver.
    • 115
    Activation of PPARα and PPARγ by Environmental Phthalate Monoesters
    • 340
    • PDF
    Activation of PPARalpha and PPARgamma by environmental phthalate monoesters.
    • C. H. Hurst, D. Waxman
    • Medicine
    • Toxicological sciences : an official journal of the Society of Toxicology
    • 2003
    • 147
    Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters.
    • 173
    • PDF
    Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates.
    • 495
    • PDF
    Molecular basis of selective PPARgamma modulation for the treatment of Type 2 diabetes.
    • 82
    Endocrine disrupting chemicals, phthalic acid and nonylphenol, activate Pregnane X receptor-mediated transcription.
    • 187
    • Highly Influential
    • PDF
    Modes of Action and Species-Specific Effects of Di-(2-ethylhexyl)Phthalate in the Liver
    • 204
    • PDF