PPAR-mediated activity of phthalates: A link to the obesity epidemic?

  title={PPAR-mediated activity of phthalates: A link to the obesity epidemic?},
  author={B. Desvergne and J. Feige and C. Casals-Casas},
  journal={Molecular and Cellular Endocrinology},
  • B. Desvergne, J. Feige, C. Casals-Casas
  • Published 2009
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • The endocrine disruption hypothesis asserts that exposure to small amounts of some chemicals in the environment may interfere with the endocrine system and lead to harmful effects in wildlife and humans. Many of these chemicals may interact with members of the nuclear receptor superfamily. Peroxisome proliferator-activated receptors (PPARs) are such candidate members, which interact with many different endogenous and exogenous lipophilic compounds. More particularly, the roles of PPARs in lipid… CONTINUE READING
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