PPAR is a very low-density lipoprotein sensor in macrophages

  title={PPAR is a very low-density lipoprotein sensor in macrophages},
  author={Ajay Chawla and Chih-Hao Lee and Yaacov Barak and Weimin He and John M Rosenfeld and Debbie Liao and Jungyeob Han and Heonjoong Kang and Ronald M Evans},
Although triglyceride-rich particles, such as very low-density lipoprotein (VLDL), contribute significantly to human atherogenesis, the molecular basis for lipoprotein-driven pathogenicity is poorly understood. We demonstrate that in macrophages, VLDL functions as a transcriptional regulator via the activation of the nuclear receptor peroxisome proliferator-activated receptor . The signaling components of native VLDL are its triglycerides, whose activity is enhanced by lipoprotein lipase… CONTINUE READING