PPAR gamma signaling exacerbates mammary gland tumor development.

  title={PPAR gamma signaling exacerbates mammary gland tumor development.},
  author={Enrique Saez and John M Rosenfeld and Antonia Livolsi and Peter Olson and Eleuterio Lombardo and Michael E. Nelson and Ester M Banayo and Robert Cardiff and Juan Carlos Izpis{\'u}a-Belmonte and Ronald M Evans},
  journal={Genes & development},
  volume={18 5},
Breast cancer cell lines that express the nuclear peroxisome proliferator-activated receptor gamma (PPAR gamma) can be prompted to undergo growth arrest and differentiation when treated with synthetic PPAR gamma ligands. To evaluate the therapeutic potential of increased PPAR gamma signaling in vivo, we generated transgenic mice that express a constitutively active form of PPAR gamma in mammary gland. These mice are indistinguishable from their wild-type littermates. However, when bred to a… CONTINUE READING

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