PPAR dual agonists: are they opening Pandora's Box?

  title={PPAR dual agonists: are they opening Pandora's Box?},
  author={Pitchal Balakumar and Madhankumar Rose and Subrahmanya S Ganti and Pawan Krishan and Manjeet Singh},
  journal={Pharmacological research},
  volume={56 2},
Cardiovascular disorders are the major cause of mortality in patients of diabetes mellitus. Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of three subtypes such as PPARalpha, PPARgamma and PPARdelta/beta. Activation of PPARalpha reduces triglycerides and involves in regulation of energy homeostasis. Activation of PPARgamma causes insulin sensitization and enhances glucose metabolism, whereas… CONTINUE READING


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