PPAR delta: a dagger in the heart of the metabolic syndrome.

  title={PPAR delta: a dagger in the heart of the metabolic syndrome.},
  author={Grant D Barish and Vihang A Narkar and Ronald M Evans},
  journal={The Journal of clinical investigation},
  volume={116 3},
Obesity is a growing threat to global health by virtue of its association with insulin resistance, glucose intolerance, hypertension, and dyslipidemia, collectively known as the metabolic syndrome or syndrome X. The nuclear receptors PPARalpha and PPARgamma are therapeutic targets for hypertriglyceridemia and insulin resistance, respectively, and drugs that modulate these receptors are currently in clinical use. More recent work on the less-described PPAR isotype PPARdelta has uncovered a dual… CONTINUE READING
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