PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis Published, JLR Papers in Press, October 16, 2004. DOI 10.1194/jlr.R400010-JLR200

@article{Li2004PPARAL,
  title={PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis Published, JLR Papers in Press, October 16, 2004. DOI 10.1194/jlr.R400010-JLR200},
  author={Andrew C. Li and C. Glass},
  journal={Journal of Lipid Research},
  year={2004},
  volume={45},
  pages={2161 - 2173}
}
The nuclear receptor superfamily is composed of transcription factors that positively and negatively regulate gene expression in response to the binding of a diverse array of lipid-derived hormones and metabolites. Intense efforts are currently being directed at defining the biological roles and mechanisms of action of liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs). LXRs have been found to play essential roles in the regulation of whole body cholesterol… Expand
LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes Published, JLR Papers in Press, September 8, 2005. DOI 10.1194/jlr.M500235-JLR200
TLDR
LXR and PPAR activators regulate the expression of SULT2B1b, the key enzyme in the synthesis of CS, which is a potent regulator of epidermal differentiation and corneocyte desquamation. Expand
Effects of PPARα on cardiac glucose metabolism: a transcriptional equivalent of the glucose-fatty acid cycle?
  • B. Finck
  • Medicine
  • Expert review of cardiovascular therapy
  • 2006
TLDR
Overexpression of the PPARα isoform in the muscle or heart of mice drives diminished glucose transporter gene expression and glucose uptake into those insulin target tissues, and studies such as this may influence the development of the next generation of PPAR ligands. Expand
Pharmacological Activation of Liver X Receptors Promotes Reverse Cholesterol Transport In Vivo
TLDR
Test the hypothesis that administration of the synthetic LXR agonist GW3965 would increase the rate of macrophage RCT in vivo and demonstrated that it significantly increased the levels of 3H-tracer in plasma and feces in all 3 mouse models. Expand
Peroxisome proliferator-activated receptors: how their effects on macrophages can lead to the development of a new drug therapy against atherosclerosis.
TLDR
With the development of drugs selectively activating PPARs, a new arsenal of drugs specifically targeting to the macrophage/foam cell may potentially have a profound impact on how the authors treat cardiovascular disease. Expand
Effects of high dietary fat and cholesterol on expression of PPARα, LXRα, and their responsive genes in the liver of apoE and LDLR double deficient mice
  • Yanyan Zou, Hui-qin Du, +6 authors Jie Pan
  • Biology, Medicine
  • Molecular and Cellular Biochemistry
  • 2008
TLDR
It is suggested that the changes of PPARα, LXRα, and their target genes aggravated lipid metabolic disorder in the liver and further accelerated the development of atherosclerosis on a stress of HF diet feeding in AL mice. Expand
Role of Liver X Receptor, Insulin and Peroxisome Proliferator Activated Receptor α on in Vivo Desaturase Modulation of Unsaturated Fatty Acid Biosynthesis
TLDR
The results indicate a necessary sophisticated interaction of all these factors to produce the physiological effects of insulin, LXR/retinoic X receptor, PPAR-α and sterol regulatory element binding protein-1c on the unsaturated fatty acid synthesis controlled by Δ6 and Δ5 desaturases. Expand
Mechanisms of Diet-induced Dyslipidemia and Insulin Resistance: Role of Chronic LXR Activation
TLDR
Data support the hypothesis that the dyslipidemic effects of dietary cholesterol are mediated at least in part by LXR, a master transcriptional regulator of cholesterol, fat and carbohydrate metabolism in the liver. Expand
On the mechanism for PPAR agonists to enhance ABCA1 gene expression.
TLDR
PPARs and LXRs are involved in the regulation of ABCA1 expression and HDL biogenesis in a cooperative signal transduction pathway. Expand
Modulation Peroxisome Proliferators Activated Receptor alpha (PPAR α) and Acyl Coenzyme A: Cholesterol Acyltransferase1 (ACAT1) Gene expression by Fatty Acids in Foam cell
TLDR
It seems that different fatty acids have different effects on gene expression and lipid metabolism and for complete conception study of the genes involved in lipid metabolism in foam cell all at once maybe is benefit. Expand
miR-613 regulates cholesterol efflux by targeting LXRα and ABCA1 in PPARγ activated THP-1 macrophages.
TLDR
It is found that miR-613 is inversely correlated with LXRα and ABCA1 in PPARγ activated THP-1 cells and this finding revealed an alternative mechanism for PParγ regulation and provided a potential target for the treatment of cholesterol metabolic diseases. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 180 REFERENCES
Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosis.
TLDR
This review summarizes recent efforts to decode the differential and overlapping roles of PPARs and LXRs in the context of macrophage lipid homeostasis and the control of inflammation. Expand
Transcriptional Regulation of Human CYP27 Integrates Retinoid, Peroxisome Proliferator-Activated Receptor, and Liver X Receptor Signaling in Macrophages
TLDR
The findings suggest that nuclear receptor-regulated CYP27 expression is likely to be a key integrator of retinoic acid receptor-PPARγ-LXR signaling, relying on natural ligands and contributing to lipid metabolism in macrophages. Expand
Identification of macrophage liver X receptors as inhibitors of atherosclerosis
TLDR
Elimination of LXR activity in bone marrow-derived cells mimics many aspects of Tangier disease, a human high density lipoprotein deficiency, including aberrant regulation of cholesterol transporter expression, lipid accumulation in macrophages, splenomegaly, and increased atherosclerosis. Expand
Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice
TLDR
It is reported that the PPARγ-specific agonists rosiglitazone and GW7845 strongly inhibited the development of atherosclerosis in LDL receptor‐deficient male mice, despite increased expression of the CD36 scavenger receptor in the arterial wall. Expand
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
TLDR
It is demonstrated here that the nonsteroidal LXR agonist GW3965 has potent antiatherogenic activity in two different murine models, providing direct evidence for an atheroprotective effect of LXRs agonists and support their further evaluation as potential modulators of human cardiovascular disease. Expand
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
TLDR
It is demonstrated that in vivo, LXR agonists reduce inflammation in a model of contact dermatitis and inhibit inflammatory gene expression in the aortas of atherosclerotic mice and LXR ligands inhibit the expression of inflammatory mediators in response to bacterial infection or LPS stimulation. Expand
PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
TLDR
It is demonstrated that PPAR-γ is neither essential for nor substantially affects the development of the macrophage lineage both in vitro and in vivo, and that inhibitory effects on cytokine production and inflammation may be receptor independent. Expand
A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis
TLDR
It is proposed that PPARγ coordinates a complex physiologic response to oxLDL that involves particle uptake, processing, and cholesterol removal through ABCA1. Expand
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
TLDR
It is demonstrated here that the nuclear receptors LXRalpha and LXRbeta and their oxysterol ligands are key regulators of apoE expression in both macrophages and adipose tissue, and a central role for LXR signaling pathways in the control of macrophage cholesterol efflux is supported. Expand
Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor
TLDR
Activation of ABC-1-mediated cholesterol efflux by the RXR/LXR heterodimer might contribute to the beneficial effects of rexinoids on atherosclerosis and warrant further evaluation of RXR or LXR agonists in prevention and treatment of Atherosclerosis. Expand
...
1
2
3
4
5
...