PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway.

@article{Bulhak2009PPARalphaAP,
  title={PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway.},
  author={Aliaksandr A Bulhak and Christian Jung and C. G. Ostenson and Jon O N Lundberg and Per-Ove Sj{\"o}quist and John Pernow},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2009},
  volume={296 3},
  pages={H719-27}
}
Several clinical studies have shown the beneficial cardiovascular effects of fibrates in patients with diabetes and insulin resistance. The ligands of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) reduce ischemia-reperfusion injury in nondiabetic animals. We hypothesized that the activation of PPAR-alpha would exert cardioprotection in type 2 diabetic Goto-Kakizaki (GK) rats, involving mechanisms related to nitric oxide (NO) production via the phosphatidylinositol 3-kinase (PI3K… CONTINUE READING