PPAR Protects Proximal Tubular Cells from Acute Fatty Acid Toxicity

@inproceedings{Kamijo2007PPARPP,
  title={PPAR Protects Proximal Tubular Cells from Acute Fatty Acid Toxicity},
  author={Yuji Kamijo and Kazuhiko Hora and Keiichi Kono and Kazuhisa Takahashi and Makoto Higuchi and Takashi Ehara and Kendo Kiyosawa and Hidekazu Shigematsu and Frank J. Gonzalez and Toshifumi Aoyama},
  year={2007}
}
Fatty acids bound to albumin are filtered through glomeruli, reabsorbed by proximal tubular epithelial cells, and metabolized. Because albumin serves as a carrier, an increase in delivery of fatty acids to the proximal tubule may occur in proteinuric states, possibly leading to toxic effects. At present, the contribution of fatty acids to tubulointerstitial damage and the mechanisms underlying this toxicity remain unclear. We recently found that the transcription factor peroxisome proliferator… CONTINUE READING

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