PPAR-– Null Mice Are Protected From High-Fat Diet – Induced Insulin Resistance

@inproceedings{GuerreMillo2001PPARNM,
  title={PPAR-– Null Mice Are Protected From High-Fat Diet – Induced Insulin Resistance},
  author={Mich{\'e}le Guerre-Millo and Christine Rouault and Philippe Poulain and Jocelyne Andr{\'e} and Vincent Poitout and Jeffrey M. Peters and Frank J. Gonzalez and J. -C. Fruchart and G{\'e}rard Reach and Bart Staels},
  year={2001}
}
Peroxisome proliferator–activated receptor (PPAR)controls the expression of genes involved in lipid metabolism. PPARfurthermore participates to maintain blood glucose during acute metabolic stress, as shown in PPAR–null mice, which develop severe hypoglycemia when fasted. Here, we assessed a potential role for PPARin glucose homeostasis in response to long-term high-fat feeding. When subjected to this nutritional challenge, PPAR–null mice remained normoglycemic and normoinsulinemic, whereas… CONTINUE READING