PPAR γ regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1

@inproceedings{Chui2005PPARR,
  title={PPAR γ regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1},
  author={Patricia C. Chui and Hong-Ping Guan and Michael Lehrke and Mitchell A Lazar},
  year={2005}
}
In addition to its role in energy storage, adipose tissue also accumulates cholesterol. Concentrations of cholesterol and triglycerides are strongly correlated in the adipocyte, but little is known about mechanisms regulating cholesterol metabolism in fat cells. Here we report that antidiabetic thiazolidinediones (TZDs) and other ligands for the nuclear receptor PPARγ dramatically upregulate oxidized LDL receptor 1 (OLR1) in adipocytes by facilitating the exchange of coactivators for… CONTINUE READING
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