PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells

@inproceedings{Kim2013PPARAI,
  title={PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells},
  author={Hyo-Sup Kim and You-Cheol Hwang and Seung-Hoi Koo and Kyong Soo Park and M V Lee and Kwang-Won Kim and Moon-Kyu Lee},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND It has been reported that peroxisome proliferator-activated receptor (PPAR)-γ and their synthetic ligands have direct effects on pancreatic β-cells. We investigated whether PPAR-γ activation stimulates insulin secretion through the up-regulation of GPR40 in pancreatic β-cells. METHODS Rat insulinoma INS-1 cells and primary rat islets were treated with rosiglitazone (RGZ) and/or adenoviral PPAR-γ overexpression. OLETF rats were treated with RGZ. RESULTS PPAR-γ activation with RGZ… CONTINUE READING
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