PPARδ regulates satellite cell proliferation and skeletal muscle regeneration

  title={PPARδ regulates satellite cell proliferation and skeletal muscle regeneration},
  author={Alison R Angione and Chunhui Jiang and Dongning Pan and Yong-Xu Wang and Shihuan Kuang},
  booktitle={Skeletal Muscle},
Peroxisome proliferator-activated receptors (PPARs) are a class of nuclear receptors that play important roles in development and energy metabolism. Whereas PPARδ has been shown to regulate mitochondrial biosynthesis and slow-muscle fiber types, its function in skeletal muscle progenitors (satellite cells) is unknown. Since constitutive mutation of Pparδ leads to embryonic lethality, we sought to address this question by conditional knockout (cKO) of Pparδ using Myf5-Cre/Pparδ flox/flox alleles… CONTINUE READING


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