PPARδ modulates lipopolysaccharide-induced TNFα inflammation signaling in cultured cardiomyocytes

@article{Ding2006PPARML,
  title={PPAR$\delta$ modulates lipopolysaccharide-induced TNF$\alpha$ inflammation signaling in cultured cardiomyocytes},
  author={Guoliang Ding and L. Cheng and Q. Qin and Sonya Frontin and Q. Yang},
  journal={Journal of Molecular and Cellular Cardiology},
  year={2006},
  volume={40},
  pages={821-828}
}
Abstract Peroxisome proliferator activated receptors (PPARs: PPARα, γ and δ) regulate fatty acid metabolism, glucose homeostasis, cell proliferation, differentiation and inflammation. Tumor necrosis factor α (TNFα) is one of the important pathological factors in inflammatory responses during the pathological progression of myocardial ischemic/reperfusion and hypertrophy. Accumulating evidence shows that synthetic ligands of PPARα and PPARγ suppress myocardial inflammatory responses, such as the… Expand
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Biology and therapeutic applications of peroxisome proliferator- activated receptors.
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