PPARδ binding to heme oxygenase 1 promoter prevents angiotensin II-induced adipocyte dysfunction in Goldblatt hypertensive rats

@inproceedings{Sodhi2014PPARBT,
  title={PPARδ binding to heme oxygenase 1 promoter prevents angiotensin II-induced adipocyte dysfunction in Goldblatt hypertensive rats},
  author={Komal Sodhi and Nitin Puri and Dong Hyun Kim and Terry D Hinds and L A Stechschulte and Gaia Favero and Luigi Rodella and J. Irwin Shapiro and David C Jude and Nader G Abraham},
  booktitle={International Journal of Obesity},
  year={2014}
}
Objective:Renin–angiotensin system (RAS) regulates adipogenic response with adipocyte hypertrophy by increasing oxidative stress. Recent studies have shown the role of peroxisome proliferator-activated receptor-δ (PPARδ) agonist in attenuation of angiotensin II-induced oxidative stress. The aim of this study was to explore a potential mechanistic link between PPARδ and the cytoprotective enzyme heme oxygenase-1 (HO-1) and to elucidate the contribution of HO-1 to the adipocyte regulatory effects… CONTINUE READING
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