PPARδ Promotes Running Endurance by Preserving Glucose.

@article{Fan2017PPARPR,
  title={PPARδ Promotes Running Endurance by Preserving Glucose.},
  author={Weiwei Fan and Wanda Waizenegger and Chun Shi Lin and Vincenzo Sorrentino and Ming-Xiao He and Christopher E Wall and Hao Li and Christopher Liddle and Ruth T Yu and Annette R. Atkins and Johan Auwerx and Michael Downes and Ronald M Evans},
  journal={Cell metabolism},
  year={2017},
  volume={25 5},
  pages={1186-1193.e4}
}
Management of energy stores is critical during endurance exercise; a shift in substrate utilization from glucose toward fat is a hallmark of trained muscle. Here we show that this key metabolic adaptation is both dependent on muscle PPARδ and stimulated by PPARδ ligand. Furthermore, we find that muscle PPARδ expression positively correlates with endurance performance in BXD mouse reference populations. In addition to stimulating fatty acid metabolism in sedentary mice, PPARδ activation potently… CONTINUE READING
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