PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

  title={PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs},
  author={T. X. He and Timothy A. Chan and Bert Vogelstein and Kenneth W. Kinzler},
colon cancer cells totally devoid of COX activity are PPARd was identified as a target of APC through the growth inhibited as effectively as cells producing COX analysis of global gene expression profiles in human (Hanif et al., 1996; Elder et al., 1997). Likewise, COX-1 colorectal cancer (CRC) cells. PPARd expression was and COX-2 null mouse embryo fibroblast cells remain elevated in CRCs and repressed by APC in CRC sensitive to the antiproliferative and antineoplastic efcells. This repression… CONTINUE READING
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