PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

@article{He1999PPARIA,
  title={PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs},
  author={T. X. He and Timothy A. Chan and Bert Vogelstein and Kenneth W. Kinzler},
  journal={Cell},
  year={1999},
  volume={99},
  pages={335-345}
}
colon cancer cells totally devoid of COX activity are PPARd was identified as a target of APC through the growth inhibited as effectively as cells producing COX analysis of global gene expression profiles in human (Hanif et al., 1996; Elder et al., 1997). Likewise, COX-1 colorectal cancer (CRC) cells. PPARd expression was and COX-2 null mouse embryo fibroblast cells remain elevated in CRCs and repressed by APC in CRC sensitive to the antiproliferative and antineoplastic efcells. This repression… CONTINUE READING
Highly Influential
This paper has highly influenced 26 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
238 Citations
72 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 238 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 72 references

Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during car- are sequence-specific transcription activators

  • C. V. Rao
  • Mol. Cell
  • 1999

Peroxisome proliferator-activated receptors: a critical link among fatty acids, gene expression and carcinogenesis

  • J. P. Vanden Heuvel
  • J. Nutr. 129, 575–580.
  • 1999
1 Excerpt

Similar Papers

Loading similar papers…