PPARγ signaling and metabolism: the good, the bad and the future

  title={PPARγ signaling and metabolism: the good, the bad and the future},
  author={Maryam Ahmadian and Jae Myoung Suh and Nasun Hah and Christopher Liddle and Annette R. Atkins and Michael Downes and Ronald M Evans},
  journal={Nature Medicine},
Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral medications for type 2 diabetes. However, their unique benefits are shadowed by the risk for fluid retention, weight gain, bone loss and congestive heart failure. This raises the question as to whether it is possible to build a safer generation of PPARγ-specific drugs that evoke fewer side effects while preserving… CONTINUE READING
Highly Influential
This paper has highly influenced 29 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 9 times over the past 90 days. VIEW TWEETS
342 Citations
142 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 342 extracted citations


Publications referenced by this paper.
Showing 1-10 of 142 references

Fibroblast growth factor - 21 regulates PPAR γ activity and the antidiabetic actions of thiazolidinediones

  • P. A. Dutchak
  • Cell
  • 2012

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator - activated receptor γ

  • W. Wei
  • Proc . Natl . Acad . Sci . USA
  • 2012

Similar Papers

Loading similar papers…