PPARγ signaling and metabolism: the good, the bad and the future

@article{Ahmadian2013PPARSA,
  title={PPARγ signaling and metabolism: the good, the bad and the future},
  author={Maryam Ahmadian and Jae Myoung Suh and Nasun Hah and Christopher Liddle and Annette R. Atkins and Michael Downes and Ronald M Evans},
  journal={Nature Medicine},
  year={2013},
  volume={99},
  pages={557-566}
}
Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral medications for type 2 diabetes. However, their unique benefits are shadowed by the risk for fluid retention, weight gain, bone loss and congestive heart failure. This raises the question as to whether it is possible to build a safer generation of PPARγ-specific drugs that evoke fewer side effects while preserving… CONTINUE READING
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