PPARγ partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes.

@article{Milton2015PPARPA,
  title={PPARγ partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes.},
  author={Flora Aparecida Milton and Aleksandra Cvoro and Ang{\'e}lica Amorim Amato and Douglas H. Sieglaff and Carly Sue Filgueira and Anithachristy Sigamani Arumanayagam and Maria do Carmo Alves de Lima and Ivan da R. Pitta and Francisco de Assis Rocha Neves and Paul D. Webb},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={464 3},
  pages={718-23}
}
Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor gamma (PPARγ) agonists that improve insulin resistance but trigger side effects such as weight gain, edema, congestive heart failure and bone loss. GQ-16 is a PPARγ partial agonist that improves glucose tolerance and insulin sensitivity in mouse models of obesity and diabetes without inducing weight gain or edema. It is not clear whether GQ-16 acts as a partial agonist at all PPARγ target genes, or whether it displays gene… CONTINUE READING
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