PPARγ is involved in the hyperglycemia-induced inflammatory responses and collagen degradation in human chondrocytes and diabetic mouse cartilages.

@article{Chen2015PPARII,
  title={PPARγ is involved in the hyperglycemia-induced inflammatory responses and collagen degradation in human chondrocytes and diabetic mouse cartilages.},
  author={Ying-ju Chen and D Chan and Kuo-Cheng Lan and Ching-Chia Wang and Chang-Mu Chen and Sung-Chuan Chao and K T Tsai and Rong-Sen Yang and Shing Hwa Liu},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2015},
  volume={33 3},
  pages={373-81}
}
Diabetic hyperglycemia has been suggested to play a role in osteoarthritis. Peroxisome proliferator-activated receptor-γ (PPARγ) was implicated in several pathological conditions including diabetes and inflammation. The detailed effects and mechanisms of hyperglycemia on cartilage damage still need to be clarified. Here, we investigated the role of PPARγ in hyperglycemia-triggered chondrocyte/cartilage damages using a human chondrocyte culture model and a diabetic mouse model. Human… CONTINUE READING