PPARγ deficiency results in reduced lung elastic recoil and abnormalities in airspace distribution

Abstract

BACKGROUND Peroxisome proliferator-activated receptor (PPAR)-gamma is a nuclear hormone receptor that regulates gene expression, cell proliferation and differentiation. We previously described airway epithelial cell PPARgamma deficient mice that develop airspace enlargement with decreased tissue resistance and increased lung volumes. We sought to understand… (More)
DOI: 10.1186/1465-9921-11-69

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