PPARγ as a therapeutic target in cystic fibrosis.

  title={PPARγ as a therapeutic target in cystic fibrosis.},
  author={Johanna F. Dekkers and Cornelis Korstiaan van der Ent and Eric Kalkhoven and Jeffrey Matthijn Beekman},
  journal={Trends in molecular medicine},
  volume={18 5},
Cystic fibrosis (CF) is characterized by a proinflammatory pulmonary condition that may result from increased infections and altered intracellular metabolism in CFTR-deficient cells. The lipid-activated transcription factor peroxisome proliferator-activated receptor-γ (PPARγ) has well-established roles in immune cell function and inflammatory modulation and has been demonstrated to play an important role in the heightened inflammatory response in CF cells. Here, we summarize current literature… CONTINUE READING
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2017