PPARγ and Apoptosis in Cancer

  title={PPARγ and Apoptosis in Cancer},
  author={Heath A. Elrod and Shi-yong R Sun},
  journal={PPAR Research},
  pages={237 - 244}
Peroxisome proliferator-activated receptors (PPARs) are ligand binding transcription factors which function in many physiological roles including lipid metabolism, cell growth, differentiation, and apoptosis. PPARs and their ligands have been shown to play a role in cancer. In particular, PPARgamma ligands including endogenous prostaglandins and the synthetic thiazolidinediones (TZDs) can induce apoptosis of cancer cells with antitumor activity. Thus, PPARgamma ligands have a potential in both… CONTINUE READING


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