PPARγ agonist pioglitazone improves scopolamine-induced memory impairment in mice.

OBJECTIVES This study was conducted to evaluate the effects of exposure to pioglitazone, a peroxisome proliferator-activated receptor agonist, on cognitive impairment induced by scopolamine, a muscarinic antagonist, in mice. METHODS Pioglitazone (9mg/kg, 18mg/kg) was orally administered for 9 days at 30min before intraperitoneal injection with scopolamine… (More)