PPARβ activation restores the high glucose-induced impairment of insulin signalling in endothelial cells.

@article{Quintela2014PPARAR,
  title={PPARβ activation restores the high glucose-induced impairment of insulin signalling in endothelial cells.},
  author={Ana Mar{\'i}a Quintela and Rosario Jimenez and Laura Piqueras and Manuel G{\'o}mez-Guzm{\'a}n and Juan Vicente Haro and Mar{\'i}a Jos{\'e} Zarzuelo and Angel Cogolludo and Mar{\'i}a Jes{\'u}s Gil Sanz and M In{\'e}s Toral and Montserrat Romero and Francisco Perez-Vizcaino and Juan Duarte},
  journal={British journal of pharmacology},
  year={2014},
  volume={171 12},
  pages={3089-102}
}
BACKGROUND AND PURPOSE PPARβ enhances insulin sensitivity in adipocytes and skeletal muscle cells, but its effects on insulin signalling in endothelial cells are not known. We analysed the effects of the PPARβ/δ (PPARβ) agonists, GW0742 and L165041, on impaired insulin signalling induced by high glucose in HUVECs and aortic and mesenteric arteries from diabetic rats. EXPERIMENTAL APPROACH Insulin-stimulated NO production, Akt-Ser(473) and eNOS-Ser(1177) phosphorylation, and reactive oxygen… CONTINUE READING
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