PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells.

  title={PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells.},
  author={David {\'A}lvarez-Guardia and Xavier Palomer and Teresa Coll and Luc{\'i}a Serrano and Ricardo Rodr{\'i}guez-Calvo and Mercy M. Davidson and Manuel Merlos and Ilhem El Kochairi and Liliane Michalik and Walter Wahli and Manuel V{\'a}zquez-Carrera},
  journal={Biochimica et biophysica acta},
  volume={1811 2},
Owing to its high fat content, the classical Western diet has a range of adverse effects on the heart, including enhanced inflammation, hypertrophy, and contractile dysfunction. Proinflammatory factors secreted by cardiac cells, which are under the transcriptional control of nuclear factor-κB (NF-κB), may contribute to heart failure and dilated cardiomyopathy. The underlying mechanisms are complex, since they are linked to systemic metabolic abnormalities and changes in cardiomyocyte phenotype… CONTINUE READING
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Activation of peroxisome proliferator-activated receptor beta}/{delta (PPAR{beta}/{delta}) inhibits LPS-induced cytokine production in adipocytes by lowering NF-{kappa} B activity via ERK1/2

  • R. Rodriguez-Calvo, L. Serrano, +8 authors M. Vazquez-Carrera
  • Diabetes 57
  • 2008
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