PPARα and γ Activation Effects of New Nor-triterpenoidal Saponins from the Aerial Parts of Anabasis articulata.

  title={PPAR$\alpha$ and $\gamma$ Activation Effects of New Nor-triterpenoidal Saponins from the Aerial Parts of Anabasis articulata.},
  author={Riham Salah El Dine and Hossam Mohamed Abdallah and Zeinab Abdel-Aziz Kandil and Ahmed A. Zaki and Shabana I Khan and Ikhlas A. Khan},
  journal={Planta medica},
  volume={85 4},
Anabasis articulata, traditionally used to treat diabetes, is rich in saponin content. This study was performed to investigate the agonistic effect of its saponins on peroxisome proliferator-activated receptor-α and peroxisome proliferator-activated receptor-γ in human hepatoma (HepG2) cells to explore the possibility of the involvement of these nuclear receptors in the mechanism of the antidiabetic effect of the plant. Chemical investigation of the n-butanol fraction resulted in the isolation… Expand
4 Citations
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