PPARα activation by MHY908 attenuates age-related renal inflammation through modulation of the ROS/Akt/FoxO1 pathway.

@article{Kim2017PPARAB,
  title={PPARα activation by MHY908 attenuates age-related renal inflammation through modulation of the ROS/Akt/FoxO1 pathway.},
  author={Ye Ra Kim and Eun Kyeong Lee and Dae Hyun Kim and Kyung Mok Kim and Bonggi Lee and Hye Jin An and June Whoun Park and Kyoung Mi Moon and Min Hi Park and Ki Wung Chung and Ji Young Park and Seong Jin Kim and Hwi Young Yun and Sujin Son and Pusoon Chun and Hyung Ryong Moon and Hae Young Chung},
  journal={Experimental gerontology},
  year={2017},
  volume={92},
  pages={87-95}
}
2-[4-(5-Chlorobenzothiazothiazol-2-yl)phenoxy]-2-methyl-propionic acid (MHY908) has been shown to prevent insulin resistance-induced hyperinsulinemia in aged rats. However, the mechanism underlying MHY908-mediated amelioration of renal inflammation with insulin resistance during aging remains unknown. This study investigated the effects of MHY908 on age… CONTINUE READING