PPARα Antagonist AA452 Triggers Metabolic Reprogramming and Increases Sensitivity to Radiation Therapy in Human Glioblastoma Primary Cells.

@article{Benedetti2017PPARAA,
  title={PPARα Antagonist AA452 Triggers Metabolic Reprogramming and Increases Sensitivity to Radiation Therapy in Human Glioblastoma Primary Cells.},
  author={Elisabetta Benedetti and Michele d'Angelo and Alessandra Ammazzalorso and Giovanni Luca Gravina and Chiara Laezza and Andrea Antonosante and Gloria Panella and Benedetta Cinque and Loredana Cristiano and Anne Chlo{\'e} Dhez and Carlo Astarita and Renato Juan Galzio and Maria Grazia Cifone and Rodolfo Ippoliti and Rosa Amoroso and Ernesto Di Cesare and Antonio Giordano and Annamaria Cimini},
  journal={Journal of cellular physiology},
  year={2017},
  volume={232 6},
  pages={1458-1466}
}
Glioblastoma (GB) is the most common cancer in the brain and with an increasing incidence. Despite major advances in the field, there is no curative therapy for GB to date. Many solid tumors, including GB, experienced metabolic reprogramming in order to sustain uncontrolled proliferation, hypoxic conditions, and angiogenesis. PPARs, member of the steroid hormone receptor superfamily, are particularly involved in the control of energetic metabolism, particularly lipid metabolism, which has been… CONTINUE READING