PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice.

@article{Ryan2004PPARgammaAR,
  title={PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice.},
  author={M. J. Ryan and Sean P. Didion and Satya N. Mathur and Frank M. Faraci and Curt D. Sigmund},
  journal={Hypertension},
  year={2004},
  volume={43 3},
  pages={661-6}
}
The peroxisome proliferator activated receptor (PPARgamma) agonist rosiglitazone has been reported to yield cardiovascular benefits in patients by a mechanism that is not completely understood. We tested whether oral rosiglitazone (25 mg/kg per day, 21 days) treatment improves blood pressure and vascular function in a transgenic mouse expressing both human renin and human angiotensinogen transgenes (R(+)A(+)). Rosiglitazone decreased systolic (138+/-5 versus 128+/-5 mm Hg) and mean blood… CONTINUE READING

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