PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta.

@article{Qian2010PP2ART,
  title={PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta.},
  author={Wei Qian and Jianhua Shi and Xiaomin Yin and Khalid Iqbal and Inge Grundke-Iqbal and C X Gong and Fei Liu},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={19 4},
  pages={1221-9}
}
Abnormal hyperphosphorylation of tau appears to be crucial in neurofibrillary degeneration in Alzheimer's disease (AD). Previous studies suggest that a down-regulation of protein phosphatase 2A (PP2A), the major tau phosphatase in human brain, contributes to tau hyperphosphorylation in AD. However, the effects of PP2A down-regulation on site-specific tau hyperphosphorylation is not well understood. In the present study, we showed that PP2A dephosphorylated tau at several phosphorylation sites… CONTINUE READING

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