PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppression.

@article{Dung2012PP2AMD,
  title={PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppression.},
  author={Tran Duc Dung and Cecilia Hsuan Day and Truong Viet Binh and C T Lin and H. -A. Hsu and C Su and Yueh-Min Lin and Fuu-Jen Tsai and Wei-Wen Kuo and Li-mien Chen and Chih-Yang Huang},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2012},
  volume={50 5},
  pages={1802-10}
}
Hepatocellular carcinoma is a common type of cancer with poor prognosis. This study examines the in vitro and in vivo mechanisms of diosmin on human hepato-cellular carcinoma HA22T cell proliferation inhibition. HA22T cells were treated with different diosmin concentrations and analyzed with Western blot analysis, MTT assay, wound healing, flow cytometry, siRNA transfection assays and co-immuno-precipitation assay. The HA22T-implanted xeno-graft nude mice model was applied to confirm the… CONTINUE READING
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