PP2A inhibition as a novel therapeutic target in castration-resistant prostate cancer

Abstract

Protein phosphatase 2A (PP2A) is a well-known tumor suppressor frequently inhibited in human cancer. Alterations affecting PP2A subunits together with the deregulation of endogenous PP2A inhibitors such as CIP2A and SET have been described as contributing mechanisms to inactivate PP2A in prostate cancer. Moreover, recent findings highlight that functional… (More)
DOI: 10.1007/s13277-015-3849-5

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