PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins

@article{Magnaudeix2013PP2ABI,
  title={PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins},
  author={Amandine Magnaudeix and Cornelia M. Wilson and Guyl{\`e}ne Page and Chantal Bauvy and Faraj Terro},
  journal={Neurobiology of Aging},
  year={2013},
  volume={34},
  pages={770-790}
}
Using cultured cortical neurons, we show that the blockade of protein phosphatase 2A (PP2A), either pharmacologically by okadaic acid or by short hairpin RNA (shRNA)-mediated silencing of PP2A catalytic subunit, inhibited basal autophagy and autophagy induced in several experimental settings (including serum deprivation, endoplasmic reticulum stress, rapamycin, and proteasome inhibition) at early stages before autophagosome maturation. Conversely, PP2A upregulation by PP2A catalytic subunit… CONTINUE READING

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