• DOI:10.1084/JEM.139.6.1529
Corpus ID: 859787

POTENTIATION OF T-CELL-MEDIATED IMMUNITY BY SELECTIVE SUPPRESSION OF ANTIBODY FORMATION WITH CYCLOPHOSPHAMIDE

@article{Lagrange1974POTENTIATIONOT,
  title={POTENTIATION OF T-CELL-MEDIATED IMMUNITY BY SELECTIVE SUPPRESSION OF ANTIBODY FORMATION WITH CYCLOPHOSPHAMIDE},
  author={P. Lagrange and G. Mackaness and T. Miller},
  journal={The Journal of Experimental Medicine},
  year={1974},
  volume={139},
  pages={1529 - 1539}
}

• P. Lagrange, G. Mackaness, T. Miller
• Published 1974
• Biology, Medicine
• The Journal of Experimental Medicine

Delayed-type hypersensitivity (DTH) appears in mice immunized with less than an optimal immunogenic dose of sheep red blood cells (SRBC), but is blocked progressively as antibody production increases in response to larger doses of SRBC. Treatment with cyclophosphamide (CY) was shown to release T cells from this inhibitory influence of the humoral response, and cause enhancement of DTH. The magnitude of this enhancing effect on T-cell activity was markedly dependent on the time of treatment… Expand

View PDF

Save to Library

Create Alert

Cite

Launch Research Feed