• Corpus ID: 201697147

POTENTIAL BENEFITS AND CONTROVERSIES RELATED TO USE OF AMYGDALIN ( VITAMIN B 17 )

@inproceedings{Jasar2018POTENTIALBA,
  title={POTENTIAL BENEFITS AND CONTROVERSIES RELATED TO USE OF AMYGDALIN ( VITAMIN B 17 )},
  author={Dzengis Jasar and Vanja Filipovski and Katerina B. Kubelka-Sabit and Biljana Curcic-Trajkovska},
  year={2018}
}
Amygdalin, also known as Vitamin B17 is often considered as anticancer remedy and can be found in many plants. Foods rich in vitamin B17 are referred to as nitrilosides, which contain cyanide that is very toxic ingredient. The aim of this article is to highlight some controversies about amygdalin’s effects. Bibliographical searches were performed in available studies and reports using the following terms: “amygdalin”, “laetrile”, “vitamin B17” and “cancer treatment”. Administration of amygdalin… 

References

SHOWING 1-10 OF 50 REFERENCES
A clinical trial of amygdalin (Laetrile) in the treatment of human cancer.
TLDR
Amygdalin (Laetrile) is a toxic drug that is not effective as a cancer treatment and patients exposed to this agent should be instructed about the danger of cyanide poisoning, and their blood cyanide levels should be carefully monitored.
Amygdalin (Laetrile) and prunasin beta-glucosidases: distribution in germ-free rat and in human tumor tissue.
TLDR
Observing the activity of beta-glucosidases that cleave glucose from amygdalin and from prunasin in tissues from germ-free rats and in normal and neoplastic human tissues poses serious questions concerning the alleged tumoricidal effect of Amygdalin.
The current status of laetrile.
TLDR
Acceptable clinical studies in humans are lacking, but such ventures would appear to be contraindicated from animal studies and observed human toxicities, and current legal-judicial aspects of laetrile therapy for cancer are discussed.
Pharmaceutical assessment of amygdalin (Laetrile) products.
TLDR
Both tablet and ampule forms of amygdalin manufactured by Cyto Pharma of Mexico are considered unfit for use in man by the National Cancer Institute.
Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells.
TLDR
It is shown that amygdalin induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells by caspase-3 activation through down-regulation of Bcl-2 and up- Regulation of Bax, a pro-apoptotic protein.
The case against laetrile. The fraudulent cancer remedy
TLDR
Laetrile (amygdalin) is not as non‐toxic as claimed, particularly when ingested orally, and especially when taken with plant material high in β‐glucosidase.
Vitamins and cancer prevention: Issues and dilemmas
TLDR
Although evidence based on studies in animal systems reveals that vitamin intake and status can modulate the outcome of experimental carcinogenesis, the findings are often conflicting and difficult to interpret, it would be inappropriate to recommend either substantial changes in habitual vitamin intakes, as provided by an adequate, well‐balanced diet, or promotion of megavitamin intakes as a means of reducing risk from cancers in the human population.
The pharmacokinetics of prunasin, a metabolite of amygdalin.
The pharmacokinetics of prunasin have been investigated in the dog. The results are compared with results obtained with amygdalin. The volume of distribution and the clearance of prunasin are larger
Inhibition of cell growth and down-regulation of telomerase activity by amygdalin in human cancer cell lines
TLDR
It is concluded that amygdalin treatment offers a valuable option for the cancer treatment, causing inhibition of cell growth and down-regulation of telomerase activity in human cancer cell lines by increasing β-glucosidase activity.
Unproved dietary claims in the treatment of patients with cancer.
TLDR
Because patients or family members read about such unproved treatments and often are concerned about their potential effectiveness, it is desirable that physicians, dietitians, and nurses have a reasonably adequate knowledge of the more common systems, at least, and know how to obtain more information.
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