• Corpus ID: 35550618

POTENTIAL ACTION OF VITAMIN-E , MORIN , RUTIN AND QUERCETIN AGAINST THE DOXORUBICIN-INDUCED CARDIOMYOPATHY Research

@inproceedings{Parabathina2011POTENTIALAO,
  title={POTENTIAL ACTION OF VITAMIN-E , MORIN , RUTIN AND QUERCETIN AGAINST THE DOXORUBICIN-INDUCED CARDIOMYOPATHY Research},
  author={Raja Kumar Parabathina and Dr. E. Muralinath and Paramjyoti L Swamy and Vinay Krishna},
  year={2011}
}

• R. K. Parabathina, Dr. E. Muralinath, +1 author V. Krishna
• Published 2011
• Medicine

The authors evaluated the influence of DOX administration on the pre-treatment of flavonoids and vitamin-E. Thirty New-Zealand white rabbits aged between 5-6 months and averaging 2.5-3.0 Kgs in weight were divided into 5 groups of 6 each and used in one week feeding trail experiment. In the present study, the development of cardiomyopathy was prevented by reducing oxidative stress using natural antioxidant vitamin E (50 IU/kg body weight) and flavonoids morin, rutin and quercetin, which are generally available in the natural diet. The seven days treatment of flavonoids (20mg/kg body weight) were affectively influenced doxorubicin (10mg/kg body weight)-induced cardiomyopathy. The flavonoids affected the levels of serum enzymes SGOT, SGPT, ALP, oxidative markers catalase (CAT), lipid peroxidation, glutathione-s-transferase (GST), reduced glutathione (GSH) both in whole erythrocytes and tissues of liver, heart and kidneys. The study concludes that the flavonoids have a protective role in the doxorubicin-induced cardiomyopathy.