POT1 association with TRF2 regulates telomere length.

@article{Kendellen2009POT1AW,
  title={POT1 association with TRF2 regulates telomere length.},
  author={Megan F. Kendellen and Katharine S. Barrientos and Christopher M. Counter},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 20},
  pages={
          5611-9
        }
}
Deleting the OB folds encoding the telomeric single-stranded DNA (ssDNA)-binding activity of the human telomeric protein POT1 induces significant telomere elongation, suggesting that at least one critical aspect of the regulation of telomere length is disrupted by this POT1(DeltaOB) mutant protein. POT1 is known to associate with two proteins through the protein interaction domain retained in POT1(DeltaOB)-the telomeric double-stranded DNA-binding protein TRF2 and the telomere-associated… CONTINUE READING

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