• Published 2004

POT 1-interacting protein PIP 1 : a telomere length regulator that recruits POT 1 to the TIN 2 / TRF 1 complex

@inproceedings{Ye2004POT1P,
  title={POT 1-interacting protein PIP 1 : a telomere length regulator that recruits POT 1 to the TIN 2 / TRF 1 complex},
  author={Jeffrey Zheng-Sheng Ye and Dirk Hockemeyer and Andrew N. Krutchinsky and Diego Loayza and Sarah M. Hooper and Brian T Chait and Titia de Lange},
  year={2004}
}
Human telomere length is controlled by a negative feedback loop based on the binding of TRF1 to doublestranded telomeric DNA. The TRF1 complex recruits POT1, a single-stranded telomeric DNA-binding protein necessary for cis-inhibition of telomerase. By mass spectrometry, we have identified a new telomeric protein, which we have named POT1-interacting protein 1 (PIP1). PIP1 bound both POT1 and the TRF1-interacting factor TIN2 and could tether POT1 to the TRF1 complex. Reduction of PIP1 or POT1… CONTINUE READING

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