Corpus ID: 40170287

POT 1-interacting protein PIP 1 : a telomere length regulator that recruits POT 1 to the TIN 2 / TRF 1 complex

  title={POT 1-interacting protein PIP 1 : a telomere length regulator that recruits POT 1 to the TIN 2 / TRF 1 complex},
  author={J. Ye and Dirk Hockemeyer and A. Krutchinsky and D. Loayza and Sarah M. Hooper and B. Chait and T. D. Lange},
  • J. Ye, Dirk Hockemeyer, +4 authors T. D. Lange
  • Published 2004
  • Human telomere length is controlled by a negative feedback loop based on the binding of TRF1 to doublestranded telomeric DNA. The TRF1 complex recruits POT1, a single-stranded telomeric DNA-binding protein necessary for cis-inhibition of telomerase. By mass spectrometry, we have identified a new telomeric protein, which we have named POT1-interacting protein 1 (PIP1). PIP1 bound both POT1 and the TRF1-interacting factor TIN2 and could tether POT1 to the TRF1 complex. Reduction of PIP1 or POT1… CONTINUE READING
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