POST-TREATMENT WITH THE NOVEL DELTORPHIN E, A &dgr;2-OPIOID RECEPTOR AGONIST, INCREASES RECOVERY AND SURVIVAL AFTER SEVERE HEMORRHAGIC SHOCK IN BEHAVING RATS

@article{Rutten2008POSTTREATMENTWT,
  title={POST-TREATMENT WITH THE NOVEL DELTORPHIN E, A \&dgr;2-OPIOID RECEPTOR AGONIST, INCREASES RECOVERY AND SURVIVAL AFTER SEVERE HEMORRHAGIC SHOCK IN BEHAVING RATS},
  author={Mikal Rutten and Meera Govindaswami and Peter R. Oeltgen and Joan Smith Sonneborn},
  journal={Shock},
  year={2008},
  volume={29},
  pages={42-48}
}
Deltorphin E was investigated as a pharmaceutical intervention in the ischemic hemorrhagic model. To monitor the hemodynamic biomarkers mean arterial pressure (MAP) and heart rate (HR) and to facilitate i.v. injections, rats were surgically fitted with femoral artery and vein catheters under anesthesia. After removal of 48% of total blood volume (range, 12-15 mL), posthemorrhage i.v. injections of 5.5-mg/kg deltorphin E were found to significantly (P < 0.05) increase maximum MAP, pulse pressure… 
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TLDR
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