POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration.

@article{Yang2012POSHLA,
  title={POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration.},
  author={Tao Yang and Yiming Sun and Feng Zhang and Yuangang Zhu and Lei Shi and Huashun Li and Zhiheng Xu},
  journal={Cell reports},
  year={2012},
  volume={2 3},
  pages={640-51}
}
The formation of proximal cytoplasmic dilation in the leading process (PCDLP) of migratory neocortical neurons is crucial for somal translocation and neuronal migration, processes that require the elaborate coordination of F-actin dynamics, centrosomal movement, and nucleokinesis. However, the underlying molecular mechanisms remain poorly understood. Here, we show that the Rac1-interacting scaffold protein POSH is essential for neuronal migration in vivo. We demonstrate that POSH is… CONTINUE READING
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