POP1 might be recruiting its type-Ia interface for NLRP3-mediated PYD-PYD interaction: Insights from MD simulation.

@article{Maharana2017POP1MB,
  title={POP1 might be recruiting its type-Ia interface for NLRP3-mediated PYD-PYD interaction: Insights from MD simulation.},
  author={Jitendra Maharana and Ashutosh Vats and Santwana Gautam and Bibhu Prasad Nayak and Sushil Kumar and Jasobanta Sendha and Sachinandan De},
  journal={Journal of molecular recognition : JMR},
  year={2017},
  volume={30 9}
}
Inflammasomes are multiprotein caspase-activating complexes that enhance the maturation and release of proinflammatory cytokines (IL-1β and IL-18) in response to the invading pathogen and/or host-derived cellular stress. These are assembled by the sensory proteins (viz NLRC4, NLRP1, NLRP3, and AIM-2), adaptor protein (ASC), and effector molecule procaspase-1. In NLRP3-mediated inflammasome activation, ASC acts as a mediator between NLRP3 and procaspase-1 for the transmission of signals. A… CONTINUE READING
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