PON1 polymorphisms are predictors of ability to attain HDL-C goals in statin-treated patients.


OBJECTIVES PON1 plays an important role in inhibiting LDL-C oxidation, which reduces atherosclerosis and cardiovascular disease. Elevated PON1 activity or levels may contribute to increased HDL-C levels, but controversy exists over the hypothesis that genetic variation in the PON1 gene locus modulates HDL-C levels and responses to statin treatment… (More)
DOI: 10.1016/j.clinbiochem.2015.06.009


4 Figures and Tables