POLYAMINE DEPLETION INDUCES NPM MODULATING STABILITY AND TRANSCRIPTIONAL ACTIVITY OF p53 IN INTESTINAL EPITHELIAL CELLS

Abstract

Our previous studies have shown that polyamines are required for normal intestinal mucosal growth and decreased levels of polyamines inhibit intestinal epithelial cell proliferation by stabilizing p53 and other growth-inhibiting proteins. Nucleophosmin (NPM) is a multifunctional protein and has been recently shown to regulate p53 activity. The current study… (More)

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