The present case showed M protein spike with varying type of plasma dyscarasias, ascites, gynaecomastia, impotence and mild acanthosis. POEMS syndrome is a rare multisystem disorder involving polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. It usually manifests in 5–6 decade of life with a mean survival period of 8 years. We report a case of a 56 years old male surviving more than 15 years with POEMS syndrome. The pathophysiology and genetics of POEMS syndrome is not well understood. An underlying plasma cell disorder is believed to be responsible for it.