PNPLA3 mediates hepatocyte triacylglycerol remodeling.

  title={PNPLA3 mediates hepatocyte triacylglycerol remodeling.},
  author={Hanna Ruhanen and Julia Perttil{\"a} and Maarit H{\"o}ltt{\"a}-Vuori and You Zhou and Hannele Yki-J{\"a}rvinen and Elina Ikonen and Reijo K{\"a}kel{\"a} and Vesa M Olkkonen},
  journal={Journal of lipid research},
  volume={55 4},
The I148M substitution in patatin-like phospholipase domain containing 3 (PNPLA3(I148M)) determines a genetic form of nonalcoholic fatty liver disease. To elucidate the mode of PNPLA3 action in human hepatocytes, we studied effects of WT PNPLA3 (PNPLA3(WT)) and PNPLA3(I148M) on HuH7 cell lipidome after [(13)C]glycerol labeling, cellular turnover of oleic acid labeled with 17 deuterium atoms ([D17]oleic acid) in triacylglycerols (TAGs), and subcellular distribution of the protein variants… CONTINUE READING
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