PMUT: a web-based tool for the annotation of pathological mutations on proteins

@article{FerrerCosta2005PMUTAW,
  title={PMUT: a web-based tool for the annotation of pathological mutations on proteins},
  author={Carles Ferrer-Costa and Josep Llu{\'i}s Gelp{\'i} and Leire Zamakola and Ivan Parraga and Xavier de la Cruz and Modesto Orozco},
  journal={Bioinformatics},
  year={2005},
  volume={21 14},
  pages={3176-8}
}
PMUT allows the fast and accurate prediction (approximately 80% success rate in humans) of the pathological character of single point amino acidic mutations based on the use of neural networks. The program also allows the fast scanning of mutational hot spots, which are obtained by three procedures: (1) alanine scanning, (2) massive mutation and (3) genetically accessible mutations. A graphical interface for Protein Data Bank (PDB) structures, when available, and a database containing hot spot… CONTINUE READING
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